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action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /home4/scienrds/scienceandnerds/wp-includes/functions.php on line 6114Source:https:\/\/www.quantamagazine.org\/how-a-dna-parasite-may-have-fragmented-our-genes-20230330\/#comments<\/a><\/br> Cl\u00e9ment Gilbert<\/a>, an evolutionary genomicist at Paris-Saclay University, thinks the aquatic bias in introners is an echo of what his group found in horizontal gene transfer events. In 2020, their work uncovered nearly 1,000 distinct horizontal transfers involving transposons that had occurred in over 300 vertebrate genomes. The vast majority of these transfers happened in teleost fish, Gilbert said.<\/p>\n If introners find their way into hosts primarily through horizontal gene transfers in aquatic environments, that could explain the irregular patterns of big intron gains in eukaryotes. Terrestrial organisms aren\u2019t likely to have the same bursts of introns, Corbett-Detig said, since horizontal transfer occurs far less often among them. The transferred introns could persist in genomes for many millions of years as permanent souvenirs from an ancestral life in the sea and a fateful brush with a deft genomic parasite.<\/p>\n Introners acting as foreign, invasive elements in genomes could also be the explanation for why they would insert introns so suddenly and explosively. Defense mechanisms that a genome might use to suppress its inherited burden of transposons might not work on an unfamiliar genetic element arriving by horizontal transfer.<\/p>\n \u201cNow that element can go crazy all over the genome,\u201d Gozashti said. Even if the introners are initially harmful, the researchers hypothesize that selective pressures could soon tame them by cutting them out of RNA.<\/p>\n Although horizontal gene transfer and introners share a connection to the aquatic environment, the findings don\u2019t yet show definitively that this is where introners come from. But the discovery of introners\u2019 widespread influence does challenge some theories about how genomes \u2014 particularly eukaryotic genomes \u2014 have evolved.<\/p>\n The pervasiveness of recent intron gain may act as a counterweight to some ideas about the evolution of genomic complexity. One example involves a theory of intron evolution developed by Michael Lynch<\/a> of Arizona State University in 2002. Models suggest that in species with small breeding populations, natural selection can be less efficient at removing unhelpful genes. Lynch proposed that those species will therefore tend to build up heaps of nonfunctional genetic junk in their genomes. In contrast, species with very large breeding populations should not be gaining many introns at all.<\/p>\n But Gozashti, Corbett-Detig and their coauthors found the opposite. Some marine protists with gargantuan breeding populations had hundreds or thousands of introners. In contrast, introners were rare in animals and absent in land plants \u2014 both groups with much smaller breeding populations.<\/p>\n The evolutionary arms race between invading genetic elements and the host may have a hand in generating a more complicated genome. The parasitic elements are in \u201cconstant conflict\u201d with genetic elements that belong to the host, Gozashti explained, because they compete for genomic space. \u201cAll these moving pieces are constantly driving each other to evolve,\u201d he said.<\/p>\n That raises the question of what the intron gains meant for the functional biology of the organisms in which they occurred.<\/p>\n Cedric Feschotte<\/a>, a molecular biologist at Cornell University, suspects it would be interesting to compare two closely related species, only one of which has experienced an intron swarm in recent evolutionary history. The comparison might help to reveal how influxes of introns could promote the appearance of new genes. \u201cBecause we know that bringing in introns can also facilitate the capture of additional exons \u2014 so completely new stuff,\u201d he said.<\/p>\n Similarly, Feschotte thinks that profusions of introns might help drive the evolution of families of genes that can change rapidly. Stuffed with new introns, those genes could co-opt the new variability enabled by alternative splicing.<\/p>\n Such rapidly evolving genes are widespread in nature. Venomous species, for instance, often need to remix the complex cocktails of peptides in their venoms at the genetic level to adapt to different prey or predators. The ability of the immune system to generate endlessly diverse molecular receptors also depends on genes that can rearrange and recombine quickly.<\/p>\n Peona warns, however, that although introners could provide benefits to an organism, they might also be totally neutral. They should be considered \u201cinnocent until proven guilty of function or anything else.\u201d<\/p>\n \u201cOne of the things that\u2019s next is looking at metagenomic data to try to find a case that really is a clear horizontal transfer with the exact same introners in two different species,\u201d Corbett-Detig said. Finding this piece of the puzzle would help flesh out the full story of where most of eukaryotes\u2019 introns have come from.<\/p>\n
\nHow a DNA \u2018Parasite\u2019 May Have Fragmented Our Genes<\/br>
\n2023-04-03 21:58:04<\/br><\/p>\nReverberations in the Host<\/strong><\/h2>\n