{"id":28550,"date":"2023-04-06T21:58:06","date_gmt":"2023-04-06T21:58:06","guid":{"rendered":"https:\/\/scienceandnerds.com\/2023\/04\/06\/animal-mutation-rates-reveal-traits-that-speed-evolution\/"},"modified":"2023-04-06T21:58:06","modified_gmt":"2023-04-06T21:58:06","slug":"animal-mutation-rates-reveal-traits-that-speed-evolution","status":"publish","type":"post","link":"https:\/\/scienceandnerds.com\/2023\/04\/06\/animal-mutation-rates-reveal-traits-that-speed-evolution\/","title":{"rendered":"Animal Mutation Rates Reveal Traits That Speed Evolution"},"content":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/animal-mutation-rates-reveal-traits-that-speed-evolution-20230405\/#comments<\/a><\/br>
\nAnimal Mutation Rates Reveal Traits That Speed Evolution<\/br>
\n2023-04-06 21:58:06<\/br><\/p>\n

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If they found a mutation in around 50% of an offspring\u2019s DNA, they concluded that it was likely a germline mutation \u2014 one inherited through either the mother\u2019s egg or the father\u2019s sperm. Natural selection can act directly on such a mutation. Less frequent mutations were deemed to have happened spontaneously in tissues outside the germline; they were less relevant to evolution because they wouldn\u2019t get passed on.<\/p>\n

(Surprisingly often, mismatches in the family trios told the researchers that the fathers listed by the zoos were unrelated to the babies. Zoo representatives would often shrug at this news and say there might have been two males in the cage. \u201cYeah, well, the other one is the winner,\u201d Bergeron would joke.)<\/p>\n

In the end, the researchers had 151 usable trios, representing species as physically, metabolically and behaviorally diverse as massive killer whales, tiny Siamese fighting fish, Texas banded geckos and humans. They then compared the species\u2019 mutation rates with what we know about the behaviors and characteristics called their life history. They also considered a statistical measure for each species called the effective population size, which roughly corresponds to how many individuals are needed to represent the genetic diversity. (For example, although the human population today is 8 billion, scientists usually estimate our effective population size to be around 10,000 or fewer.) Bergeron and her colleagues looked for patterns of associations in the numbers.<\/p>\n

The most surprising finding that emerged from the data was the wide range of germline mutation rates. When the researchers measured how often the mutations occurred per generation, the species varied by only about fortyfold, which Bergeron said seemed quite small compared to the differences in body size, longevity and other traits. But when they looked at the mutation rates per year rather than per generation, the range increased to about 120-fold, which was larger than previous studies had suggested.<\/p>\n

The Sources of Variation<\/strong><\/h2>\n

The study authors found that the higher the average effective population size for a species, the lower its mutation rate. That provided good evidence for the \u201cdrift-barrier hypothesis<\/a>,\u201d which Lynch devised a little over a decade ago. \u201cSelection is relentlessly trying to reduce the mutation rate because most mutations are deleterious,\u201d Lynch explained. But in species with smaller effective population sizes, natural selection gets weaker because genetic drift \u2014 the effect of pure chance on the spread of a mutation \u2014 gets stronger. That allows the mutation rate to rise.<\/p>\n

The findings also support another idea in the scientific literature, the male-driven evolution hypothesis<\/a>, which proposes that males may contribute more mutations to the evolution of some species than females do. Bergeron and her colleagues found that germline mutation rates tended to be higher for males than for females \u2014 at least in mammals and birds, though not in reptiles and fish.<\/p>\n

The authors noted a possible reason for those differences: Because males in all species copy their DNA constantly to make sperm, they face endless opportunities for mutations to occur. Female fish and reptiles make eggs throughout their lifetimes too, so they run a similar risk of genetic error. But female mammals and birds are essentially born with all the egg cells they will ever produce, so their germlines are more protected.<\/p>\n

Life history traits accounted for about 18% of the variation that the researchers found. The biggest of those effects came from a species\u2019 generation time, the average age at which it reproduces: As the age of the parents rose, so did the mutation rates.<\/p>\n

Because Bergeron included herself, her brother and their parents in the study for human data, she can see this pattern in her own family. \u201cI carry more mutations than my brother, because my dad was older when he had me,\u201d she said.<\/p>\n

Factors like maturation time and numbers of offspring also played a role for some vertebrates, but contrary to expectations, the researchers didn\u2019t find any effect related to body size. There\u2019s a long-standing hypothesis that creatures with bigger body sizes should have more mutations<\/a> because they have more cells and thus more opportunities for the DNA-copying machinery to make mistakes.<\/p>\n

\u201cIt was surprising to see that generation time seemed a lot more important than body size,\u201d said Kelley Harris<\/a>, an assistant professor of genome sciences at the University of Washington. \u201cIn the previous literature, those hypotheses are more on equal footing.\u201d<\/p>\n

Harris commended the findings as an exciting start to answering some of these big questions about what factors are the most important determiners of mutation rate and thus evolution. Beyond that, the study hints at just how much biodiversity exists in nature.<\/p>\n

\u201cThe diversity of life isn\u2019t just what animals look like,\u201d she said. There are \u201call these traits that you can\u2019t see, and being able to observe it in studies like this just makes biodiversity even more exciting.\u201d<\/p>\n<\/div>\n

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\nSource:https:\/\/www.quantamagazine.org\/animal-mutation-rates-reveal-traits-that-speed-evolution-20230405\/#comments<\/a><\/br><\/br><\/p>\n","protected":false},"excerpt":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/animal-mutation-rates-reveal-traits-that-speed-evolution-20230405\/#comments Animal Mutation Rates Reveal Traits That Speed Evolution 2023-04-06 21:58:06 If they found a mutation in around 50% of an offspring\u2019s DNA, they concluded that it was likely a germline mutation \u2014 one inherited through either the mother\u2019s egg or the father\u2019s sperm. Natural selection can act directly on such a mutation. Less frequent […]<\/p>\n","protected":false},"author":1,"featured_media":28551,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"pagelayer_contact_templates":[],"_pagelayer_content":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-28550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nAnimal Mutation Rates Reveal Traits That Speed Evolution - Science and Nerds<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceandnerds.com\/2023\/04\/06\/animal-mutation-rates-reveal-traits-that-speed-evolution\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Animal Mutation Rates Reveal Traits That Speed Evolution - Science and Nerds\" \/>\n<meta property=\"og:description\" content=\"Source:https:\/\/www.quantamagazine.org\/animal-mutation-rates-reveal-traits-that-speed-evolution-20230405\/#comments Animal Mutation Rates Reveal Traits That Speed Evolution 2023-04-06 21:58:06 If they found a mutation in around 50% of an offspring\u2019s DNA, they concluded that it was likely a germline mutation \u2014 one inherited through either the mother\u2019s egg or the father\u2019s sperm. 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