wp-plugin-hostgator domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /home4/scienrds/scienceandnerds/wp-includes/functions.php on line 6114ol-scrapes domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /home4/scienrds/scienceandnerds/wp-includes/functions.php on line 6114Source:https:\/\/www.quantamagazine.org\/selfish-virus-like-dna-can-carry-genes-between-species-20230803\/#comments<\/a><\/br> Previous studies of horizontal transfers have often focused on the mobile genetic elements called transposons. These privileged \u201cjumping genes\u201d can hop around the genome of an organism by replicating themselves and inserting their copies. Their sole concern is to promote their own survival within the genome rather than the fitness of the organism, which is why they are often categorized as \u201cselfish\u201d genes. Because roundworms have a rapid life cycle and a simple body plan, they are ideal model organisms for studying this kind of genetic parasitism.<\/p>\n Some roundworms carry a genetic element that is so fascinatingly selfish, the survival of offspring hinges on inheriting at least one copy of it. It contains a duo of genes, one encoding a toxic protein and one encoding an antidote that neutralizes the toxin. A mother worm that carries this element deposits the toxin in her eggs. When the eggs are fertilized, only offspring that can express the antidote gene survive. It is as if the toxin-antidote element<\/a> has taken the worm\u2019s genome hostage to ensure its propagation.<\/p>\n In 2021, when Israel Campo Bes<\/a> was a graduate student at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna, he sometimes worked late on looking for genes linked to the toxin-antidote genetic elements in various roundworms. One breezy summer night at almost 2 a.m., he noticed something. The toxin gene in one worm looked almost exactly like a gene for a different function in another species of worm. They were astonishingly similar \u2014 with nearly 97% nucleotide similarity. \u201cIt looked as if one worm had copied its genes and somehow pasted them into the genome of the other,\u201d he said.<\/p>\n \u201cI found it quite surprising as well,\u201d said Alejandro Burga<\/a>, the senior molecular geneticist at the laboratory. To uncover the origin of the shared elements, Burga and team decided to examine the surrounding DNA. They spotted repeated sequences in the DNA flanking the genes \u2014 a feature of transposons that aids their jumping within a genome by ensuring that the inserted copies keep the right orientation. The team also discovered the remnants of several viral genes: one for an enveloping capsid protein, one that commonly aids viral replication, and one for a \u201cglue\u201d that integrates viral DNA into a host genome.<\/p>\n \u201cIt was like an archaeological dig \u2014 we kept uncovering clues,\u201d Burga said.<\/p>\n The complete picture of the genome revealed that the shuttled gene was embedded within a set of virus-like genes and a transposon, all of which Burga recognized as making up a Maverick<\/em>.<\/p>\n Mavericks<\/em> are an ancient and fragmented class of jumping genes prevalent in the genomes of protists, fungi and animals, including humans. These massive mobile elements were initially assumed to be inactive, mutated relics of obsolete genes. But later research revealed that Mavericks<\/em> can be reactivated, and that they can mediate horizontal gene transfer between some species of protists<\/a>. Complete, intact Mavericks<\/em> had never been characterized in a multicellular organism. The roundworms therefore presented a rare opportunity to study them.<\/p>\n The Maverick<\/em> in one of these roundworms, however, had an additional gene \u2014 one encoding a protein called a fusogen that enables a virus to fuse with a cell and transfer its genome into it. \u201cWithout fusogen, there would be no way for the virus to transfer its genes,\u201d said Sonya Angeline Widen<\/a>, a postdoctoral researcher in Burga\u2019s laboratory and co-lead author with Bes of the new study. The discovery of the protein strongly suggested that this Maverick <\/em>had the ability to form a virus-like particle and invade different cell types.<\/p>\n Burga\u2019s team quickly mined the roundworm genome database for other examples of genes embedded like cargo for transport in Mavericks<\/em>. It soon became evident that the one they had found was not an isolated case of horizontal gene transfer. In more than 100 roundworm genomes spanning 11 or more genera, two families of genes had often been taken up as cargo by the Maverick<\/em> particles and extensively transferred between species. Complete and incomplete remains of the genetic elements permeated different worm populations around the globe, from North America to India to a kilometer-deep gold mine in South Africa.<\/p>\n Although the circumstantial evidence strongly suggests that this Maverick<\/em> enabled the horizontal transfer of genes between the roundworm species, researchers have not yet caught it in the act. Burga and his team recognize that their important next step will be to find a way to induce virus-like Maverick<\/em> particles to form while they observe them under a microscope.<\/p>\n The work could have a practical benefit. Many roundworm species are parasites that infect agricultural crops and livestock. If researchers understand how Mavericks<\/em> work, it might be possible to use them to control the parasites by introducing genes into them.<\/p>\n \u201cIt is not something we can do right way,\u201d Burga said, \u201cbut hopefully in a few years.\u201d<\/p>\n There is reason to believe that gene transfer using massive transposons may be more common in nature. Recent research led by Aaron Vogan<\/a> of Uppsala University in Sweden has found massive mobile genetic elements called Starships<\/em><\/a> that shuttle genes around in multiple species of fungi. Vogan suspects that Starships<\/em> transferring key genes between fungal pathogens may have created the new strains that cause rolling epidemics of wheat diseases, such as tan spot (yellow leaf spot). The diseases have caused major crop losses worldwide since the 1970s, with over 50% loss of harvest in extreme cases. \u201cSo understanding the dynamics of changes in genome from such horizontal gene transfer has impacts all across biology,\u201d Vogan said.<\/p>\n Researchers have come to appreciate that transposon-like genetic elements are \u201ckey drivers of genome evolution,\u201d Zanders said. To really understand genomes, we must understand these \u201cselfish elements\u201d that can jump between species, she added.<\/p>\n<\/div>\n <\/br><\/br><\/br><\/p>\n
\nSelfish, Virus-Like DNA Can Carry Genes Between Species<\/br>
\n2023-08-07 21:58:16<\/br><\/p>\nPasting Genes Between Genomes<\/strong><\/h2>\n
Mavericks<\/strong> Do the Unorthodox<\/strong><\/h2>\n