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{"id":38282,"date":"2023-11-22T21:58:42","date_gmt":"2023-11-22T21:58:42","guid":{"rendered":"https:\/\/scienceandnerds.com\/2023\/11\/22\/in-the-guts-second-brain-key-agents-of-health-emerge\/"},"modified":"2023-11-22T21:58:43","modified_gmt":"2023-11-22T21:58:43","slug":"in-the-guts-second-brain-key-agents-of-health-emerge","status":"publish","type":"post","link":"https:\/\/scienceandnerds.com\/2023\/11\/22\/in-the-guts-second-brain-key-agents-of-health-emerge\/","title":{"rendered":"In the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge"},"content":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/in-the-guts-second-brain-key-agents-of-health-emerge-20231121\/#comments<\/a><\/br>
\nIn the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge<\/br>
\n2023-11-22 21:58:42<\/br><\/p>\n

\n

The experiment offered clear evidence that, in addition to other cells, \u201cglial cells can also sense physical forces\u201d through this mechanosensory channel, said Vassilis Pachnis<\/a>, the head of the nervous system development and homeostasis laboratory at the Francis Crick Institute. Then, having sensed the change in force, they can shift the activity of neural circuits to trigger muscular contractions. \u201cIt\u2019s a wonderful piece of work,\u201d he said.<\/p>\n

Hub cells are only one of many glial subtypes that play functional roles in the gut. Scavuzzo\u2019s new six subtypes, added to those characterized in previous research<\/a>,<\/u> together reveal 14 known subgroups of glia across the duodenum, ileum and colon. More are likely to be discovered in coming years, each with new potential to better explain how digestion works and enable researchers to develop treatments for a variety of gastrointestinal disorders.<\/p>\n

A Pain in the Gut<\/strong><\/h2>\n

Gastrointestinal diseases often come with a dose of pain, in addition to disruptive digestive issues. Eating the wrong food, or too much of the right one, can cause a stomachache. Those gut feelings are driven by enteric nerve cells, including glia. Because glia are now known to control the activity of immune cells, they are suspected to play a role in many gastrointestinal disorders and diseases, making them good potential targets for treatments.<\/p>\n

Several years ago, Pachnis and his group found that glia are among the first cell types to respond to injury or inflammation in the mouse gut, and that tampering with enteric glial cells can also create an inflammatory response. In the gut glia seem to perform roles similar to those of true immune cells, Pachnis said, and so their dysfunction can lead to chronic autoimmune disorders and\u00a0inflammatory bowel diseases<\/a>, such as ulcerative colitis and Crohn\u2019s disease. \u201cGlial cells definitely play a role in the initiation, the pathogenesis and the progression of the various diseases of the gut,\u201d he said.<\/p>\n

Glia are likely involved because of their central role in communicating between the microbiome, immune cells and other gut cells. Healthy glia strengthen the intestines\u2019 epithelial barrier, a layer of cells that keeps out toxins and pathogens and absorbs nutrients. But in patients with Crohn\u2019s disease, glial cells don\u2019t function properly, resulting in a weaker barrier and inappropriate immune response.<\/p>\n

\u201cDifferent subtypes of glia can be functioning differently or dysfunctioning in a wide range of diseases and disorders where motility is impacted,\u201d Scavuzzo said. They have also been linked to neural inflammation, hypersensitivity in the organs and even neuron death.<\/p>\n

For instance, Gulbransen and his team recently discovered that glia contribute to gut pain<\/a> by secreting molecules that sensitize neurons. This is likely an adaptive response intended to draw the gut\u2019s attention to damaging substances to dispose of them, Gulbransen said, which as a side effect causes pain.<\/p>\n

The findings, published today in Science Signaling<\/em>, suggest that targeting glia could help alleviate some of the pain created by inflammatory disorders of the gut.<\/p>\n

Glia themselves can also become stressed by genetic problems, exposure to metabolites from the microbiome, bad diet or other factors. Fattahi has observed that, no matter the cause, stressed enteric glia influence the entire tissue, and sometimes even damage neighboring neurons or recruit immune cells, causing additional inflammation and pain.<\/p>\n

These new studies in enteric glia will go a long way toward explaining many gastrointestinal disorders that researchers have struggled to understand and treat, Sharkey said. \u201cI\u2019m really excited to see how these cells have evolved to become central figures in enteric neurobiology over the years.\u201d<\/p>\n

It\u2019s becoming ever clearer that the neuron doesn\u2019t act alone in the enteric system, he added. \u201cIt\u2019s got these beautiful partners in glia that really allow it to do its thing in the most efficient and effective way.\u201d<\/p>\n

Quanta\u00a0is conducting a series of surveys to better serve our audience. Take our\u00a0biology reader survey<\/a>\u00a0and you will be entered to win free<\/em>\u00a0Quanta\u00a0merchandise.<\/em><\/p>\n<\/div>\n

<\/br><\/br><\/br><\/p>\n

Uncategorized<\/br>
\n<\/br>
\nSource:https:\/\/www.quantamagazine.org\/in-the-guts-second-brain-key-agents-of-health-emerge-20231121\/#comments<\/a><\/br><\/br><\/p>\n","protected":false},"excerpt":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/in-the-guts-second-brain-key-agents-of-health-emerge-20231121\/#comments In the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge 2023-11-22 21:58:42 The experiment offered clear evidence that, in addition to other cells, \u201cglial cells can also sense physical forces\u201d through this mechanosensory channel, said Vassilis Pachnis, the head of the nervous system development and homeostasis laboratory at the Francis Crick Institute. Then, having […]<\/p>\n","protected":false},"author":1,"featured_media":38283,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"pagelayer_contact_templates":[],"_pagelayer_content":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-38282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nIn the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge - Science and Nerds<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceandnerds.com\/2023\/11\/22\/in-the-guts-second-brain-key-agents-of-health-emerge\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge - Science and Nerds\" \/>\n<meta property=\"og:description\" content=\"Source:https:\/\/www.quantamagazine.org\/in-the-guts-second-brain-key-agents-of-health-emerge-20231121\/#comments In the Gut\u2019s \u2018Second Brain,\u2019 Key Agents of Health Emerge 2023-11-22 21:58:42 The experiment offered clear evidence that, in addition to other cells, \u201cglial cells can also sense physical forces\u201d through this mechanosensory channel, said Vassilis Pachnis, the head of the nervous system development and homeostasis laboratory at the Francis Crick Institute. 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