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{"id":39262,"date":"2024-02-22T21:59:15","date_gmt":"2024-02-22T21:59:15","guid":{"rendered":"https:\/\/scienceandnerds.com\/2024\/02\/22\/a-multitalented-scientist-seeks-the-origins-of-multicellularity\/"},"modified":"2024-02-22T21:59:17","modified_gmt":"2024-02-22T21:59:17","slug":"a-multitalented-scientist-seeks-the-origins-of-multicellularity","status":"publish","type":"post","link":"https:\/\/scienceandnerds.com\/2024\/02\/22\/a-multitalented-scientist-seeks-the-origins-of-multicellularity\/","title":{"rendered":"A Multitalented Scientist Seeks the Origins of Multicellularity"},"content":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/a-multitalented-scientist-seeks-the-origins-of-multicellularity-20240221\/#comments<\/a><\/br>
\nA Multitalented Scientist Seeks the Origins of Multicellularity<\/br>
\n2024-02-22 21:59:15<\/br><\/p>\n

\n

You did your postdoc with the zoologist Michael Akam<\/a> at Cambridge. In an era when biochemistry predominates, the study of whole animals can sometimes seem like a throwback to another century. Why did you choose it?<\/strong><\/h3>\n

Because I wanted to take the findings in my dissertation to the next step. The dissertation examined how germ cells behaved in one animal. At Cambridge, I asked how germ cells behaved in all animals and how they evolved. To do that, I studied sea urchins, crustaceans and sea anemones in the lab. Then I read the historic literature, just about everything published on the germ cells of hundreds of different species.<\/p>\n

Throughout my career, I\u2019ve tried to build on previous findings, and that sometimes means going outside of the original discipline or stretching its definitions. Right now, in my lab, we\u2019re trying to understand the evolution of development by considering more than genes.<\/p>\n

We are incorporating ecology and environment into our studies. Instead of just studying fruit flies in isolation, we are looking at the microbes that live inside the flies and the plants that the flies feed on. With this work, we hope to understand how the developmental processes can evolve in real-life environments.<\/p>\n

What would you say are the most important findings to come from your Harvard lab?<\/strong><\/h3>\n

First, showing that cell-cell signaling is not an unusual way for animals to generate embryonic germ cells<\/a> \u2014 that is, cells that will become eggs and sperm. The idea that dominated textbooks for most of the 20th century was that in insects and most other animals, a \u201cgerm plasm\u201d in the egg established a distinct lineage of germ cells very early in development. But we showed that in crickets, body cells are induced to change into germ cells by signals from the surrounding tissues. That\u2019s what happens in mice and other mammals, too, but it was thought to be a novel mechanism that appeared rarely in evolution.<\/p>\n

Second, discovering in 2020 that the long-lost relatives of oskar<\/em>, a gene very famous for its essential role in insect reproduction, were actually from bacteria<\/a>, not just from earlier animals. This gene evolved by fusion of bacterial genome sequences with animal genome sequences. It suggests that the forerunners to oskar<\/em> had very different functions, possibly in the development of the nervous system, and that further study of how it evolved its new purpose could be highly informative.<\/p>\n

Third, falsifying century-old \u201claws\u201d that predicted the shapes of biological structures. Insect eggs vary tremendously, by eight orders of magnitude in size and with wildly different shapes. Previous assumptions were that a universal \u201claw\u201d of some kind, that applied to all animals, could explain the evolution of the shapes and sizes of cells and of structures made of cells. In the case of eggs, there were many previous hypotheses about what these laws were, including, for example, that the dimensions of the eggs reflected the requirements of the developmental rate or the adult body size for each species.<\/p>\n

But we constructed an unparalleled data set\u00a0of over 10,000 measurements of insect eggs and found that what really best predicted the size and shape of an egg was where it would be laid. Eggs laid on the ground or under leav<\/a>es are basically elliptical. Eggs laid in the water tend to be smaller and more spherical. Parasitoid eggs laid inside other insects are also small but asymmetrical.<\/p>\n

How did you come to move your work from Cambridge to Harvard?<\/strong><\/h3>\n

In 2003, Harvard invited me to give a seminar. Afterward, people said, \u201cDo you know that there\u2019s an assistant professorship opening in evolutionary developmental biology? You should apply.\u201d<\/p>\n

I was perfectly happy at Cambridge. I had just gotten four years\u2019 worth of funding for research. Frankly, I didn\u2019t think I\u2019d get the job because I had a pretty clear idea of what Harvard was looking for and it didn\u2019t look like me. I was surprised to receive an offer.<\/p>\n

Within a few years, you won tenure. In fact, you became the first Black woman to be tenured in the biological sciences at Harvard\u2019s Faculty of Arts and Sciences. Did that feel good \u2014 or like a burden?<\/strong><\/h3>\n

Both. Listen, this was not the first time in my life that I\u2019ve been a \u201cfirst.\u201d Being the only Black woman in an all-white environment is essentially the story of my professional life. My chosen field of work is predominantly white. Often, whenever I do anything professionally, I\u2019m the first Black woman to have done it. That\u2019s not a reflection on me. That\u2019s a reflection on the field.<\/p>\n

Have you experienced any bias at Harvard?<\/strong><\/h3>\n

I have not experienced a huge amount of deliberate blockage or targeted discrimination. But things often happen. I\u2019ll turn up at the door for something and am told to use the service entrance. \u201cOh, I\u2019m here for the [Harvard] Corporation dinner,\u201d I explain. \u201cOh yes, the service entrance is around the back.\u201d<\/p>\n

Or I\u2019m the keynote speaker at a conference. I\u2019ll go to the front desk and hear, \u201cAre you waiting for someone?\u201d<\/p>\n

It\u2019s so constant. Saying that we should react like \u201cit\u2019s water off a duck\u2019s back\u201d implies that there\u2019s no residue left behind. There\u2019s a huge buildup of scar tissue. I can\u2019t use my brain space to hold every single one of those because I need my brain space to do other things.<\/p>\n<\/div>\n

<\/br><\/br><\/br><\/p>\n

Uncategorized<\/br>
\n<\/br>
\nSource:
https:\/\/www.quantamagazine.org\/a-multitalented-scientist-seeks-the-origins-of-multicellularity-20240221\/#comments<\/a><\/br><\/br><\/p>\n","protected":false},"excerpt":{"rendered":"

Source:https:\/\/www.quantamagazine.org\/a-multitalented-scientist-seeks-the-origins-of-multicellularity-20240221\/#comments A Multitalented Scientist Seeks the Origins of Multicellularity 2024-02-22 21:59:15 You did your postdoc with the zoologist Michael Akam at Cambridge. In an era when biochemistry predominates, the study of whole animals can sometimes seem like a throwback to another century. Why did you choose it? 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